云南籍几个正常人群间GSTM1 基因多态性的比较研究

doi:10.3969/j.issn.1004-616x.2002.01.007

癌变·畸变·突变 ›› 2002, Vol. 14 ›› Issue (1): 22-024.doi: 10.3969/j.issn.1004-616x.2002.01.007

云南籍几个正常人群间GSTM1 基因多态性的比较研究

梁子卿1 ; 宋忠魁1 ;夏晓玲2 ;黄云超2 ;镡　颖1 ;汪　旭1 3

1. 云南师范大学生命科学学院遗传教研室,云南　昆明　650092 ; 　2. 昆明医学院第二附属医院胸外科,云南　昆明 650031

收稿日期:2001-05-08 修回日期:2001-07-24 出版日期:2002-01-30 发布日期:2002-01-30
通讯作者: 梁子卿

STUDY OF GENETIC POLYMORPHISM OF GLUTATHIONE S2TRANSFERASE M1 AMONG THREE SUBPOPULATIONS IN YUNNAN PROVINCE

LIANG Zi-qing1; SONG Zhong-kui1 ; XIA Xiao-ling2 ; HUANG Yun-chao2 ; CHAN Ying; WANG Xu1

1. Genetic Section , School of Life Sciences , Yunnan Normal University , Kunming 650092 , China ; 2. Chest Surgical

Received:2001-05-08 Revised:2001-07-24 Online:2002-01-30 Published:2002-01-30
Contact: LIANG Zi-qing

摘要/Abstract

摘要： 目的: 针对云南曲靖地区宣威县、富源县及非曲靖地区3 组正常人群进行GSTM1 基因型多态性的比较研究。方法:采用聚合酶链反应(Polymerase chain reaction ,PCR) 技术对相关人群进行基因型鉴定。结果: GSTM1 纯合缺失基因型(0/ 0) 的频率在宣威人群为63. 6 %(n = 33) ,富源人群为64. 5 %(n = 31) ,非曲靖人群为68. 5 %(n = 35) 。结论: GSTM1 基因型多态性在3 个正常人群中的分布情况均一。该研究为了解特定地区肺癌与外源物代谢解毒基因之间的可能联系提供了一些基础数据。

关键词: 谷胱甘肽硫转移酶M1 基因, 遗传多态性, 正常人群, 云南人群

Abstract: Purpose : To compare the genetic polymorphism of glutathione S-transferase M1 (GSTM1) locus between the populations in Xuanwei and Fuyuan counties in Qujing city and between Qujing and non-Qujing residents in Yunnan province. Methods : Polymerase chain reaction ( PCR) was employed to justify the genotype of the aim population. Results : No significant difference was found in the GSTM1 genotype frequencies among those three groups ( P > 0. 05) , i . e. , the frequencies of GSTM1 null genotype (0/ 0) were 63. 6 % in Xuanwei residents , 64. 5 % in Fuyuan group and 68. 5 % in non-Qujing group , respectively. Conclusion : Among the normal populations studied , the genetic polymorphism distribution of GSTM1 genes was proved to be homogenous. The result is helpful for further research on the association on lung cancer and xenobiotics detoxification genes.

Key words: GSTM1 gene, genotype polymorphism, normal population, “Yunnan”population

中图分类号:

Q319

梁子卿 , 宋忠魁 , 夏晓玲 , 黄云超 , 镡　颖 , 汪　旭 . 云南籍几个正常人群间GSTM1 基因多态性的比较研究[J]. 癌变·畸变·突变, 2002, 14(1): 22-024.

LIANG Zi-qing, SONG Zhong-kui , XIA Xiao-ling , HUANG Yun-chao , CHAN Ying, WANG Xu. STUDY OF GENETIC POLYMORPHISM OF GLUTATHIONE S2TRANSFERASE M1 AMONG THREE SUBPOPULATIONS IN YUNNAN PROVINCE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(1): 22-024.

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[4]	林国芳1, 马晴雯1, 查永林2, 娄克俭2, 陈纪刚3, 沈建华1. 上海“本地人”正常人群GSTT1 和GSTM1 基因型多态性研究[J]. , 2001, 13(1): 10-012.
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云南籍几个正常人群间GSTM1 基因多态性的比较研究

STUDY OF GENETIC POLYMORPHISM OF GLUTATHIONE S2TRANSFERASE M1 AMONG THREE SUBPOPULATIONS IN YUNNAN PROVINCE

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